I am the clinical-academic lead of the MND Centre at Queen Square, Institute of Neurology, UCL, and I have 20-year experience in multi-disciplinary care and research in MND and neuromuscular disorders.
My research group’ main interest is the characterization of mechanisms of neurodegeneration and neuroinflammation which can be modelled into novel disease biomarkers and therapeutic targets. I have been instrumental in the development of large UK-wide longitudinal biobanking projects encompassing the natural history of MND.
My research focus is the study of circulating biomarkers which mirror the neuroinflammatory milieu embedding degenerating neurons and derived from neuroaxonal structural decomposition. I have been at the forefront of the development and optimization of assays for biomarkers like neurofilaments now central to clinical trial design and in the application of proteomics to study complex matrices like plasma.
I have recently worked on immunological senescence and dysregulation driving disease progression in MND and I am part of UK-wide and international academic consortia and clinical trial platforms driving therapeutic development in MND.