Linda Greensmith

Linda Greensmith

Programme Lead

University College London

Professor Linda Greensmith is an elected Fellow of The Academy of Medical Sciences and The Royal Society of Biology. She runs the Graham Watts Laboratories for Research into Motor Neuron Disease (MND) at UCL and is the Scientific Director of The UCL Queen Square MND Centre.

Her research is focused on improving our understanding of the pathophysiology of motor neuron degeneration and muscle paralysis, and in developing novel therapeutic approaches for MND/ALS. Her group uses a wide range of techniques, ranging from whole animal physiology to RNA transcriptomics. Her group is recognized for their expertise in mouse models of MND/ALS and for undertaking preclinical trials, with the aim of translating these findings into disease modifying therapies for patients.

Her group successfully developed Arimoclomol, a novel compound targeting protein dyshomeostasis, through pre-clinical testing in cellular and animal models of MND/ALS in the lab into clinical trials in MND/ALS patients.